Hyperglycaemia and renal ischaemia-reperfusion injury
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چکیده
منابع مشابه
Hemeoxygenase-1 and renal ischaemia-reperfusion injury.
Degradation by the inducible enzyme hemeoxygenase-1 (HO-1) is the principal route of mammalian heme metabolism. The resultant generation of free iron, carbon monoxide and biliverdin results in myriad actions including promoting cell survival, circulatory integrity and immunomodulation. This review examines the evidence from both human studies and work performed in experimental models implicatin...
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BACKGROUND Renal ischaemia-reperfusion (I-R) can cause acute tubular necrosis and chronic renal deterioration. Endoglin, an accessory receptor for Transforming Growth Factor-beta1 (TGF-beta1), is expressed on activated endothelium during macrophage maturation and implicated in the control of fibrosis, angiogenesis and inflammation. METHODS Endoglin expression was monitored over 14 days after ...
متن کاملthe effect of nitroprusside on the renal ischaemia-reperfusion injury
nitric oxide (no) is implicated as an important mediator of, or intermediary in, inflammation, immunity and neurotransmission. in the kidney, no is involved in haemodynamic regulation, control of vascular tone and tubular function. formation of oxygen-derived free radicals (ofr) have been documented in renal ischaemia- reperfusion before. in this study , we investigated the significance of no f...
متن کاملVascular ischaemia and reperfusion injury.
Although restoration of blood flow to an ischaemic organ is essential to prevent irreversible tissue injury, reperfusion per se may result in a local and systemic inflammatory response that may augment tissue injury in excess of that produced by ischaemia alone. Cellular damage after reperfusion of previously viable ischaemic tissues is defined as ischaemia-reperfusion (I-R) injury. I-R injury ...
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Hyperglycaemia during acute myocardial infarction is common and associated with increased mortality. Thioredoxin-interacting protein (Txnip) is a modulator of cellular redox state and contributes to cell apoptosis. This study aimed to investigate whether or not hyperglycaemia enhances Txnip expression in myocardial ischaemia/reperfusion (MI/R) and consequently exacerbates MI/R injury. Rats were...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2003
ISSN: 1460-2385
DOI: 10.1093/ndt/18.3.460